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公开(公告)号:US20090221702A1
公开(公告)日:2009-09-03
申请号:US11908671
申请日:2006-03-17
IPC分类号: A61K31/235 , C07C59/68 , A61K31/192 , A61K31/12 , C07C49/255 , C07C39/16 , A61K31/055 , C07C69/65 , A61P35/00
CPC分类号: A61K31/05 , A61K31/085 , A61K31/137
摘要: The present invention provides the use of a compound of the Formula: (I) wherein R1 is C1-5 alkoxy, OCOC1-3Alkyl, O(CH2)2O(CH2)2O(CH2)2OMe, O(CH2)2O(CH2)2O(CH2)2OH or OH; R2 is H, (CH2)nOH, OCH3, Hal or (II) or (III) R3 is H or (CH2)nOH; and R4 is C1-6 alkyl, optionally substituted by one or more of Hal, OH, COCH3, NH2, NHCH3, NHMe, NMe2, OCOCH3, CO2H or esters or amides thereof where n is 1-5; and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in modulating PKB activity.
摘要翻译: 本发明提供式(I)化合物或其盐,其中R 1为C 1-5烷氧基,OCOC 1-3烷基,O(CH 2)2 O(CH 2)2 O(CH 2)2 OMe,O(CH 2)2 O(CH 2) 2 O(CH 2)2 OH或OH; R2是H,(CH2)nOH,OCH3,Hal或(Ⅱ)或(Ⅲ)R3是H或(CH2)nOH; 且R 4为C 1-6烷基,任选被Hal,OH,COCH 3,NH 2,NHCH 3,NHMe,NMe 2,OCOCH 3,CO 2 H中的一种或多种或其中n为1-5的其酯或酰胺取代; 和其药学上可接受的盐在制备用于调节PKB活性的药物中的用途。