公开(公告)号：US20080163902A1

公开(公告)日：2008-07-10

申请号：US12031149

申请日：2008-02-14

Applicant: Rudolf MUELLER

Inventor： Rudolf MUELLER

IPC: B08B13/00 ,  F01D25/00

CPC classification number: F02C7/30 ,  B08B3/02 ,  F01D25/002 ,  F01D25/007 ,  F02B39/16 ,  F02C6/12 ,  F05D2220/40

Abstract: Rotor blades and hub of the impeller are cleaned by means of a cleaning fluid jet which is directed along the rotational axis of the impeller onto the impeller. The cleaning fluid jet in this case is directed, or sprayed, towards the impeller by a feed nozzle which is arranged on the axis and oriented in the direction of the impeller along the axis. The feed jet in this case follows the axis and therefore strikes the hub of the impeller in the rotational center of the impeller. This achieves the effect of the cleaning fluid striking the impeller in the rotational center of the impeller. The cleaning fluid flows, therefore, along the hub surface and is carried radially into the radially outer regions by means of centrifugal forces.

Abstract translation: 叶轮的转子叶片和轮毂通过沿着叶轮的旋转轴线引导到叶轮上的清洁流体喷射器被清洁。 在这种情况下，清洁流体射流通过沿着轴线布置在叶轮方向上的进给喷嘴引导或喷射到叶轮。 在这种情况下，进料射流跟随轴线，因此在叶轮的旋转中心处撞击叶轮的轮毂。 这实现了在叶轮的旋转中心处冲击叶轮的清洁流体的效果。 因此，清洁流体沿着毂表面流动并且通过离心力径向地径向地进入径向外部区域。

公开(公告)号：US20120122861A1

公开(公告)日：2012-05-17

申请号：US13348171

申请日：2012-01-11

Applicant: Rudolf MUELLER ,  Leslie J. STREET

Inventor： Rudolf MUELLER ,  Leslie J. STREET

IPC: A61K31/5386 ,  A61P25/00 ,  A61P11/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  C07D498/08 ,  A61P25/28

CPC classification number: C07D498/08 ,  A61K31/5375 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, among others. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

Abstract translation: 本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。 参与如记忆障碍相关的认知能力的这些脑网络，例如在各种痴呆症中观察到的，在不同脑区域之间的神经元活动不平衡中，正如帕金森病，精神分裂症，睡眠呼吸暂停症， 注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的疾病，以及诸如卒中诱发的中枢性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性通气不足综合征等疾病。 在一个特定方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。