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公开(公告)号：US08498688B2
公开(公告)日：2013-07-30
申请号：US12530786
申请日：2008-03-17
IPC分类号： A61B5/05
CPC分类号： G01R33/485 , G01R33/281 , G01R33/4824 , G01R33/5601 , G01R33/561
摘要： A device for magnetic resonance imaging of a body placed in an examination volume is configured to generate a series of MR spin echo signals from a first nuclear spin species by subjecting at least a portion of the body to an MR imaging pulse sequence. The MR imaging pulse sequence includes a spatially non-selective excitation RF pulse, a plurality of refocusing RF pulses, and a plurality of phase encoding switched magnetic field gradients. The device is further is configured to acquire the MR spin echo signals without application of frequency encoding magnetic field gradients; and to reconstruct an MR image from the acquired MR spin echo signals.
摘要翻译： 配置在检查体积中的身体的磁共振成像的装置被配置为通过使身体的至少一部分经受MR成像脉冲序列从第一核自旋物种产生一系列MR自旋回波信号。 MR成像脉冲序列包括空间非选择性激发RF脉冲，多个重聚焦RF脉冲以及多个相位编码切换磁场梯度。 该装置还被配置为在不施加频率编码磁场梯度的情况下获取MR自旋回波信号; 并从所获取的MR自旋回波信号重构MR图像。
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公开(公告)号：US20120128589A1
公开(公告)日：2012-05-24
申请号：US13387748
申请日：2010-07-21
CPC分类号： A61K49/1809 , A61K49/10 , A61K49/1881 , B82Y5/00
摘要： Described is the use of perfluoro-t-butyl cyclohexane in a contrast agent for molecular imaging, notably F MRI. Particularly, the perfluoro-t-butyl cyclohexane is present in the form of an aqueous emulsion of nanoparticles comprising the perfluoro compound as a core, and an emulsifying agent, such as a phospholipid, as a shell. The shell can be functionalized with other moieties that play a role in imaging, notably ligands for targeted binding and/or contrast agents or labels with a view to other imaging modalities. The latter particularly refers to 1H MRI contrast agents as well as radiolabels for SPECT.
摘要翻译： 描述了在造影剂中使用全氟叔丁基环己烷进行分子成像，特别是F MRI。 特别地，全氟叔丁基环己烷以包含全氟化合物为核心的纳米颗粒的水性乳液和乳化剂如磷脂作为壳体的形式存在。 壳可以与在成像中起作用的其它部分官能化，特别是用于靶向结合和/或造影剂或标签的配体，以期考虑其它成像方式。 后者特别指的是1H MRI造影剂以及用于SPECT的放射性标记。
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公开(公告)号：US20100036235A1
公开(公告)日：2010-02-11
申请号：US12530786
申请日：2008-03-17
CPC分类号： G01R33/485 , G01R33/281 , G01R33/4824 , G01R33/5601 , G01R33/561
摘要： The invention relates to a device for magnetic resonance imaging of a body (7) placed in an examination volume. The device (1) is arranged to a) generate a series of MR spin echo signals from a first nuclear spin species by subjecting at least a portion of the body (7) to an MR imaging pulse sequence comprising a spatially non-selective excitation RF pulse, a plurality of refocusing RF pulses, and a plurality of phase encoding switched magnetic field gradients; b) acquire the MR spin echo signals without application of frequency encoding magnetic field gradients; c) reconstruct an MR image from the acquired MR spin echo signals.
摘要翻译： 本发明涉及一种放置在检查体中的身体（7）的磁共振成像装置。 装置（1）被布置成：a）通过使身体（7）的至少一部分经受包括空间非选择性激发RF的MR成像脉冲序列，从而产生来自第一核自旋物种的一系列MR自旋回波信号 脉冲，多个重聚焦RF脉冲和多个相位编码切换磁场梯度; b）获取MR自旋回波信号，而不应用频率编码磁场梯度; c）从所获取的MR自旋回波信号重建MR图像。
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