Separation of salts of citric acid from fermentation broth with a weakly
basic anionic exchange resin adsorbent
    3.
    发明授权
    Separation of salts of citric acid from fermentation broth with a weakly basic anionic exchange resin adsorbent 失效
    用弱碱性阴离子交换树脂吸附剂从发酵液中分离柠檬酸盐

    公开(公告)号:US4924027A

    公开(公告)日:1990-05-08

    申请号:US275827

    申请日:1988-11-25

    IPC分类号: C07C51/47

    CPC分类号: C07C51/47

    摘要: Salts of citric acid are separated from a fermentation broth by a two-step process utilizing an adsorbent comprising a water-insoluble, macroreticular gel, weakly basic, anionic exchange resin possessing tertiary amine functional groups or pyridine functional groups, said anionic exchange resin comprising a crosslinked acrylic or styrene resin matrix and a desorbent comprising water or dilute sulfuric acid. The pH of the feed, a fermentation broth, containing citric acid, is adjusted and maintained below the first ionization constant (pKa.sub.1) of citric acid to maintain selectivity in the first step wherein citric acid is adsorbed onto the adsorbent. Then, citric acid is converted to a salt by a reaction with an aqueous alkaline liquid solution and is eluted immediately at the void volume in the alkaline solution.

    摘要翻译: 柠檬酸的盐通过使用包含具有叔胺官能团或吡啶官能团的水不溶性大网状凝胶,弱碱性阴离子交换树脂的吸附剂的两步法从发酵液中分离,所述阴离子交换树脂包含 交联的丙烯酸或苯乙烯树脂基质和包含水或稀硫酸的解吸剂。 调节饲料的pH,含有柠檬酸的发酵肉汤,并将其保持在柠檬酸的第一电离常数(pKa1)以下,以保持第一步中的选择性,其中柠檬酸被吸附到吸附剂上。 然后,通过与碱性液体水溶液的反应将柠檬酸转化成盐,并在碱性溶液中的空隙体积下立即洗脱。