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公开(公告)号：US20240360522A1
公开(公告)日：2024-10-31
申请号：US18287776
申请日：2022-04-21
发明人： Bassel Ghaddar , Subhajyoti De
IPC分类号： C12Q1/689 , C12Q1/6886 , C12Q1/6895
CPC分类号： C12Q1/689 , C12Q1/6886 , C12Q1/6895 , C12Q2600/118 , C12Q2600/158
摘要： Disclosed herein are systems and methods for identifying biomarkers. Biomarker identification can be achieved while increasing efficiency and decreasing data and computation complexity but maintaining accuracy. Such biomarker identification can be achieved via analysis of differential gene expression, such as determined using single cell RNA-sequencing data sets.
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2.发明公开公开(公告)号：US20240180981A1
公开(公告)日：2024-06-06
申请号：US18287763
申请日：2022-04-21
发明人： Bassel Ghaddar , Subhajyoti De
IPC分类号： A61K35/76 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/7068 , A61K33/243 , A61K47/64 , A61P35/00 , C12Q1/6886 , C12Q1/689 , C12Q1/70
CPC分类号： A61K35/76 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/7068 , A61K33/243 , A61K47/643 , A61P35/00 , C12Q1/6886 , C12Q1/689 , C12Q1/70 , C12Q2600/118 , C12Q2600/158
摘要： Disclosed herein are methods of identifying and treating subjects with cancer, and methods of predicting a survival outcome in a subject with cancer, such as pancreatic cancer. In one aspect, the application provides methods for detecting the presence of cancer or infectious disease in a subject by collecting and analyzing sequencing information from the subject, such as by performing single cell RNA sequencing analysis of individual cells obtained from a sample from the subject. In a further aspect, the application provides methods for detecting the presence of cancer or infectious disease in a subject by determining microbial diversity and/or assessing the presence or absence of particular microbes in individual cells from the subject as compared to a control. Also provided are methods of determining T-cell microenvironment reaction, for example by sequencing nucleic acid molecules in individual T-cells obtained from the subject.
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