公开(公告)号：US3637699A

公开(公告)日：1972-01-25

申请号：US3637699D

申请日：1970-02-24

Applicant: SANDOZ AG

Inventor： GABEL LLOYD P ,  SIMPSON WILLIAM R J

IPC: C07D491/04 ,  C07D51/48

CPC classification number: C07D491/04 ,  Y10S514/929

Abstract: DISCLOSED ARE COMPOUNDS OF THE CLASS OF QUINAZOLINES SUBSTITUTED IN THE BENZENE RING PORTION OF THE QUINAZOLINE BY LOWER ALKYL AND FURTHER SUBSTITUTED AT THE 4-POSITION BY AN AMINO FUNCTION BEARING A HYDROXYALKYL NITRATE MOIETY, E.G., 4-(5-HYDROXYPENTYL)AMINO-7,8 - DIMETHYLQUINAZOLINE NITRATE. THE COMPOUDNS HAVE PHARMACOLOGICAL ACTIVITY IN ANIMALS AND ARE USEFUL, FOR EXAMPLE, AS HYPOTENSIVE AND CORONARY DILATING AGENTS. ALSO DISCLOSED ARE THE CORRESPONDING HYDROXY INTERMEDIATES USEFUL IN PREPARATION OF THE NIRATES.

公开(公告)号：US3908011A

公开(公告)日：1975-09-23

申请号：US47760974

申请日：1974-06-10

Applicant: SANDOZ AG

Inventor： GABEL LLOYD P ,  SIMPSON WILLIAM R

IPC: A61K31/495 ,  C07D239/94 ,  C07D403/04 ,  A61K31/505

CPC classification number: C07D403/04 ,  A61K31/495 ,  C07D239/94

Abstract: Disclosed are compounds of the class of quinazolines substituted in the benzene ring portion of the quinazoline by trialkoxy and further substituted at the 4- position by an amino function bearing a hydroxyalkyl nitrate moiety, e.g., 4-(5hydroxypentyl)amino-6,7,8-trimethoxyquinazoline nitrate. The compounds have pharmacological activity in animals and are useful, for example, as hypotensive, coronary dilators and antianginal agents. Also disclosed are the corresponding hydroxy intermediates useful in preparation of the nitrates.

Abstract translation: 公开了在喹唑啉的苯环部分被三烷氧基取代的喹唑啉类化合物，并在4-位被氨基官能团带有硝酸羟烷基部分取代，例如4-（5-羟基戊基）氨基-6， 7,8-三甲氧基喹唑啉硝酸盐。 该化合物在动物中具有药理活性，并且可用作例如降血压，冠状动脉扩张剂和抗血管药。 还公开了可用于制备硝酸盐的相应的羟基中间体。

公开(公告)号：US3637701A

公开(公告)日：1972-01-25

申请号：US3637701D

申请日：1969-06-26

Applicant: SANDOZ AG

Inventor： GABEL LLOYD P ,  SIMPSON WILLIAM R J

IPC: C07D491/04 ,  C07D51/48

CPC classification number: C07D491/04 ,  Y10S514/929

Abstract: THE INVENTION DISCLOSED COMPOUNDS OF THE CLASS WHICH ARE NITRATES OF 4-SUBSTITUTED-AMINO-QUINAZOLINES, E.G., 4(2-HYDROXYETHYL)AMINO-6,7-DIMETHOXYQUINAZOLINE NITRATE, HAVING PHARMACOLOGICAL ACTIVITY IN ANIMALS AND USEFUL, FOR EXAMPLE, AS HYPOTENSIVE AND ANTI-ANGINAL AGENTS. ALSO DISCLOSED ARE THE HYDROXY INTERMEDIATES USEFUL IN PREPARATION OF SAID NITRATES.

公开(公告)号：US3637700A

公开(公告)日：1972-01-25

申请号：US3637700D

申请日：1970-11-13

Applicant: SANDOZ AG

Inventor： GABEL LLOYD P ,  SIMPSON WILLIAM R J

IPC: C07D239/94 ,  C07D403/04 ,  C07D31/48

CPC classification number: C07D403/04 ,  C07D239/94 ,  Y10S514/929

Abstract: DISCLOSED ARE COMPOUNDS OF THE CLASS OF QUINAZOLINES SUBSTITUTED IN THE BENZENE RING PORTION OF THE QUINAZOLINE BY TRIALKOXY AND FURTHER SUBSTITUTED AT THE 4-POSITION BY AN AMINO FUNCTION BEARING A HYDROXYALKYL NITRATE MOIETY, E.G., 4-(5-HYDROXYPENTYL) AMINO-6,7,8-TRIMETHOXYQUINAZOLINE NITRATE. THE COMPOUNDS HAVE PHARMACOLOGICAL ACTIVITY IN ANIMALS AND ARE USEFUL, FOR EXAMPLE, AS HYPOTENSIVE, CORONARY DILATORS AND ANTIANGINAL AGENTS. ALSO DISCLOSED ARE THE CORRESPONDING HYDROXY INTERMEDIATES USEFUL IN PREPARATION OF THE NITRATES.