公开(公告)号：US11098102B2

公开(公告)日：2021-08-24

申请号：US16709208

申请日：2019-12-10

申请人： SANOFI

发明人： Maria Mendez Perez ,  Nils Rackelmann ,  Laurent Bialy ,  Stefan Guessregen ,  Martin Will ,  Thomas Boehme ,  Ana Villar Garea ,  Marcus Hermann Korn ,  Melissa Besenius ,  Jens Riedel ,  Ulrich Werner ,  Michael Podeschwa

IPC分类号： A61K47/64 ,  C07K14/62 ,  A61K31/18

摘要： The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.