公开(公告)号：US20240059644A1

公开(公告)日：2024-02-22

申请号：US18269510

申请日：2021-12-21

申请人： SANYO CHEMICAL INDUSTRIES, LTD. ,  JUNTENDO EDUCATIONAL FOUNDATION

发明人： Yuta MURAKAMI ,  Kenichiro NAKAI ,  Nozomi OTA ,  Shihei MOTOFUJI ,  Tetsuya NAKAMURA ,  Yuka MATSUMOTO

IPC分类号： C07C229/24

CPC分类号： C07C229/24

摘要： Provided is a compound (Z) represented by the formula (1) or (2) below. In the formulas (1) and (2), Xs in each of the formulas (1) and (2) are each independently a carboxy group, a carboxylate group, or a monovalent group represented by the formula (3); at least one of Xs in each of the formulas (1) and (2) is a carboxy group or a carboxylate group; and at least one of Xs in each of the formulas (1) and (2) is a monovalent group represented by the formula (3) —C(O)—Y-(AO)n—R (3). In the formula (3), —Y— is —O—, —NH—, or —S—; A is a C2-C4 alkylene group; R is a hydrogen atom or a C1-C15 monovalent hydrocarbon group in which a hydrogen atom is optionally substituted with a C1-C10 alkoxy group; n is an integer of 4 to 1000; at least one of n As is an ethylene group; and when the formulas (1) and (2) each have multiple monovalent groups represented by the formula (3), each of —Y—, A, R, and n is the same or different among the monovalent groups.

公开(公告)号：US20210363300A1

公开(公告)日：2021-11-25

申请号：US16957203

申请日：2018-12-21

申请人： SANYO CHEMICAL INDUSTRIES, LTD.

发明人： Shihei MOTOFUJI ,  Kenichiro NAKAI ,  Kyosuke MICHIGAMI ,  Itsuka MATSUMOTO

IPC分类号： C08G65/333 ,  C08G65/26 ,  C08L71/02

摘要： The present invention provides a raw material for bulk drugs and a pharmaceutical additive which provide excellent formulation stability and excellent over-time stability of drug efficacy when used to modify a bulk drug, a polypeptide, a bioactive protein, an enzyme, and the like. The present invention relates to a raw material for bulk drugs or a pharmaceutical additive, containing: a polyether composition (A) represented by formula (1), wherein the polyether composition (A) has a unimodal molecular weight distribution, the polyether composition (A) has a ratio (Mw/Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) of 1.20 or less, and the polyether composition (A) contains a compound in which m is 1 in formula (1) in an amount of 90 wt % or more based on the weight of the polyether composition (A), in formula (1), OR1, R2O, R3O, and R4O are each independently a C2-C8 oxyalkylene group; when each of these moieties exists in the plural number, each OR1, each R2O, each R3O, and each R4O may be the same as or different from each other; these moieties may be bonded randomly or in block; a, b, c, and d are each independently an integer of 50 to 1200; X1 to X4 are each independently a hydrogen atom, a substituent represented by formula (2), or a substituent represented by formula (3); and m is an integer of 1 to 10.