公开(公告)号：US3901876A

公开(公告)日：1975-08-26

申请号：US28897372

申请日：1972-09-14

申请人： SCHERING AG

发明人： VORBRUGGEN HELMUT ,  KOPP RUDOLF ,  HOROWSKI REINHARD ,  PASCHELKE GERT ,  PALENSCHAT DIETER

IPC分类号： C07H19/167 ,  C07H19/16 ,  C07D51/54

CPC分类号： C07H19/16

摘要： Adenosine derivatives of the formula

WHEREIN A is saturated or unsaturated, straight-chain, branched or cyclic alkylene optionally substituted by one of hydroxy, acyloxy, carboxy or acyl; X is a valence bond, oxygen, sulfur, or an alkylated or acylated imino group; and B is 3-indolyl or 4imidazolyl optionally substituted by one or more of halogen, alkyl, haloalkyl, alkoxy, aryloxy, acyloxy, hydroxy, mercapto, alkylmercapto, nitro, carboxy, carboxyalkyl, or methylsulfonylamino, and processes for their preparation and use. These adenosine derivatives exert pharmacological effects on the central nervous system, the circulation, and the heart.