公开(公告)号：US20110311537A1

公开(公告)日：2011-12-22

申请号：US13222759

申请日：2011-08-31

申请人： SCOTT MELLIS ,  MARGARET KAROW ,  GEORGE D. YANCOPOULOS ,  JOANNE PAPADOPOULOS

发明人： SCOTT MELLIS ,  MARGARET KAROW ,  GEORGE D. YANCOPOULOS ,  JOANNE PAPADOPOULOS

IPC分类号： A61K39/395 ,  A61P29/00

CPC分类号： C07K14/7155 ,  A61K38/00 ,  A61K38/177 ,  A61K45/06 ,  A61K2300/00

摘要： Methods of treating, inhibiting, or ameliorating Familial Mediterranean Fever (FMF) by administering to a subject in need thereof a therapeutically effective amount of an interleukin 1 (IL-1) antagonist, are provided. The IL-1 antagonist can be an antibody or derivative thereof, which is capable of blocking or inhibiting the biological action of IL-1, thereby treating, inhibiting or ameliorating FMF. Also provided are methods of treating, inhibiting, or ameliorating FMF by administering a therapeutically effective amount of an IL-1 antagonist in combination with additional therapeutic agents, including IL-1-specific fusion proteins, TNF inhibitors, NSAIDs, steroids, and the like.

摘要翻译： 提供了通过向有需要的受试者施用治疗有效量的白细胞介素1（IL-1）拮抗剂来治疗，抑制或改善家族性地中海热（FMF）的方法。 IL-1拮抗剂可以是抗体或其衍生物，其能够阻断或抑制IL-1的生物学作用，从而治疗，抑制或改善FMF。 还提供了通过将治疗有效量的IL-1拮抗剂与另外的治疗剂（包括IL-1特异性融合蛋白，TNF抑制剂，NSAID，类固醇等）组合施用来治疗，抑制或改善FMF的方法 。