公开(公告)号：US20230131201A1

公开(公告)日：2023-04-27

申请号：US18087545

申请日：2022-12-22

申请人： SEED HEALTH, INC.

发明人： Sheri Simmons ,  Shanthi Parkar ,  Erin A. Miller ,  Joseph E. Kovarik

IPC分类号： A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17

摘要： Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. A topical application of Lactobacillus crispatus is employed to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne. The topical application of Lactobacillus crispatus to an individual's skin reduces inflammation through the production of tryptophan metabolites that act as AHR agonists.