公开(公告)号：US20110065153A1

公开(公告)日：2011-03-17

申请号：US12915793

申请日：2010-10-29

申请人： SEIKO OTSUNA ,  MASAKAZU SUGIMOTO ,  MASAKO IZUI ,  ATSUSHI HAYAKAWA ,  EIICHI NAKANO ,  MASAKI KOBAYASHI ,  YASUHIKO YOSHIHARA ,  TSUYOSHI NAKAMATSU

发明人： SEIKO OTSUNA ,  MASAKAZU SUGIMOTO ,  MASAKO IZUI ,  ATSUSHI HAYAKAWA ,  EIICHI NAKANO ,  MASAKI KOBAYASHI ,  YASUHIKO YOSHIHARA ,  TSUYOSHI NAKAMATSU

IPC分类号： C12P13/08

CPC分类号： C12N9/0016 ,  C12N9/1217 ,  C12N9/88 ,  C12N15/52 ,  C12N15/77 ,  C12P13/08

摘要： The ability and speed with which a coryneform bacterium can produce L-lysine are improved when the coryneform bacterium contains an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized. This is accomplished by successively enhancing the DNA coding for dihydrodipicolinate reductase, the DNA coding for dihydrodipicolinate synthase, the DNA coding for diaminopimelate decarboxylase, and the DNA coding for diaminopimelate dehydrogenase.

摘要翻译： 当棒状细菌含有其中L-赖氨酸和L-苏氨酸的反馈抑制基本上脱敏的天冬氨酸激酶时​​，棒状细菌可以产生L-赖氨酸的能力和速度得到改善。 这是通过连续增强编码二氢吡啶二羧酸还原酶的DNA，编码二氢吡啶二羧酸合成酶的DNA，编码二氨基庚二酸脱羧酶的DNA和编码二氨基庚二酸脱氢酶的DNA来实现的。