专利检索 ap:("SERUM INSTITUTE OF INDIA PRIVATE LIMITED") AND inv:"Vinit Kumar" 第 1 页

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发明授权
Stable vaccine compositions comprising inter alia live attenuated recombinant flavivirus and process for preparation thereof 有权

公开(公告)号：US11660333B2

公开(公告)日：2023-05-30

申请号：US16756227

申请日：2018-10-10

申请人： SERUM INSTITUTE OF INDIA PRIVATE LIMITED

发明人： Rajeev Mhalasakant Dhere , Leena Ravindra Yeolekar , Vinit Kumar , Rohit Bapurav Sonar , Sandeep Dinkar Baraskar , Rajeev Mehla , Shashikant Janardan Ghodekar , Cyrus Soli Poonawalla , Adar Cyrus Poonawalla

IPC分类号： A61K39/12 , C12N7/06 , A61K39/00

CPC分类号： A61K39/12 , C12N7/06 , A61K2039/5254 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/55583 , C12N2770/24134

摘要： Stable lyophilized immunogenic compositions include inter alia live attenuated recombinant flaviviruses, more preferably live attenuated recombinant dengue viruses, at least one carbohydrate, at least one amino acid and is particularly amenable to rapid freeze-drying treatments wherein, the composition preserves desired characteristics of a virus, including virus viability, immunogenicity and stability. The immunogenic composition is devoid of preservatives, polymers and surfactants. The methods for manufacturing the stable lyophilized immunogenic compositions are also provided.