公开(公告)号：US10800776B2

公开(公告)日：2020-10-13

申请号：US16302154

申请日：2017-05-17

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Hong Liu ,  Yu Zhou ,  Wenjing Xia ,  Dong Zhang ,  Hualiang Jiang ,  Kaixian Chen

IPC: A61K31/4196 ,  A61K31/437 ,  C07D471/04 ,  A61P25/18 ,  A61P25/28 ,  A61K31/5377 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/4709 ,  A61K31/496 ,  A61P25/22 ,  A61P25/24

Abstract: A fluorine-containing triazolopyridine represented by formula (I) and a racemate, R-stereoisomer, S-stereoisomer, pharmaceutically acceptable salt, or mixture thereof are described. The triazolopyridine can be used as a positive allosteric modulator of an mGluR2, and is highly selective in activating the mGluR2, exerting no activation or very limited activation of other homologous metabotropic glutamate receptor. The triazolopyridine can thus be used to prepare a product for treating an mGluR2-related disease, such as a central nervous system disease or neurological disease.