公开(公告)号：US20190135818A1

公开(公告)日：2019-05-09

申请号：US16304508

申请日：2017-05-24

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Hualiang JIANG ,  Hong LIU ,  Meiyu GENG ,  Mingyue ZHENG ,  Jing AI ,  Yulan WANG ,  Xiaowei WU ,  Shuangjie LI ,  Xia PENG ,  Chunpu LI ,  Kaixian CHEN ,  Bao WANG

IPC: C07D487/04 ,  A61P35/00

Abstract: The present invention provides a compound comprising a 5-membered heterocycle fused with a pyridazinone, wherein the compound is used as an FGFR kinase inhibitor, and a manufacturing method and application thereof. The invention specifically provides a compound as represented by formula (I). Various radicals are as defined in the specification. The compound provided by the invention effectively inhibits an activity of an FGFR kinase, and can be used to manufacture a pharmaceutical product for treating a disease related to the activity of the FGFR kinase.