公开(公告)号：US10710996B2

公开(公告)日：2020-07-14

申请号：US15575903

申请日：2016-05-23

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Yaqiu Long ,  Meiyu Geng ,  Zhongliang Xu ,  Jing Ai

IPC: C07D471/04 ,  A61K31/501 ,  A61K31/4985 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/5377 ,  A61P35/00

Abstract: The present invention discloses a pyrido-azacyclic compound represented by formula I, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a preparation process thereof and a composition comprising the compound, and a use thereof as a multi-target protein kinase inhibitor in the preparation of a medicament for the treatment of diseases that are associated with protein kinase, especially c-Met, such as cancer and the like. The compound represented by formula I has potent inhibitory activity on tumor cells with overexpression of c-Met kinase, can effectively target c-Met-mediated signaling pathway, and can be used in the treatment of diseases such as cancer and the like that is caused by the overexpression of c-Met kinase.