公开(公告)号：US20170066723A1

公开(公告)日：2017-03-09

申请号：US15120771

申请日：2015-02-15

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Wenhu DUAN ,  Jian DING ,  Yongcong LV ,  Hua XIE

IPC: C07D231/56 ,  C07D261/20 ,  C07D413/12 ,  C07D401/12 ,  C07D491/048 ,  C07D495/04

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D401/12 ,  C07D413/12 ,  C07D491/048 ,  C07D495/04

Abstract: The present invention relates to a naphthylamide compound of the structure as represented by formula (I), medicinal salts, prodrugs and hydrates or solvates thereof, and also relates to a method of preparing the compounds, pharmaceutical compositions comprising the compounds and the uses thereof as protein tyrosine kinase inhibitors, particularly as VEGFR-2 inhibitors, in preparing drugs for preventing and treating diseases related to abnormal angiogenesis.

Abstract translation: 本发明涉及由式（I）表示的结构的萘酰胺化合物，其药物盐，前药和水合物或溶剂化物，还涉及制备该化合物的方法，包含该化合物的药物组合物及其用途为 蛋白酪氨酸激酶抑制剂，特别是作为VEGFR-2抑制剂，在制备用于预防和治疗与异常血管生成有关的疾病的药物中。