公开(公告)号：US09914707B2

公开(公告)日：2018-03-13

申请号：US15120771

申请日：2015-02-15

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Wenhu Duan ,  Jian Ding ,  Yongcong Lv ,  Hua Xie

IPC: C07D231/56 ,  C07D261/20 ,  C07D413/12 ,  C07D401/12 ,  C07D491/048 ,  C07D495/04

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D401/12 ,  C07D413/12 ,  C07D491/048 ,  C07D495/04

Abstract: The present invention relates to a naphthylamide compound of the structure as represented by formula (I), medicinal salts, prodrugs and hydrates or solvates thereof, and also relates to a method of preparing the compounds, pharmaceutical compositions comprising the compounds and the uses thereof as protein tyrosine kinase inhibitors, particularly as VEGFR-2 inhibitors, in preparing drugs for preventing and treating diseases related to abnormal angiogenesis.