公开(公告)号：US20210079019A1

公开(公告)日：2021-03-18

申请号：US16625391

申请日：2018-06-21

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA,CHINESE ACADEMY OF SCIENCES

Inventor： Yushe YANG ,  Yinyong ZHANG ,  Chenghui SHI ,  Qian CHEN

IPC: C07D498/22 ,  A61P31/04

Abstract: Disclosed in the present invention are a thiazolidone spiro pyrimidine trione compound, a preparation method therefor and uses thereof, the compound having a structure represented by formula (I). In the formula, the definitions of the substituents are described in the specification and the claims. The thiazolidone spiro pyrimidine trione compound in the present invention has high in vivo and in vitro antibacterial activity, has better metabolic properties, and is obviously superior to existing compounds of the same kind.