公开(公告)号：US20250066509A1

公开(公告)日：2025-02-27

申请号：US18724948

申请日：2022-12-29

Applicant: SHANGHAI JMT-BIO TECHNOLOGY CO., LTD.

Inventor： Xu FENG ,  Liping SONG ,  Yi FAN ,  Yali MENG

IPC: C07K16/40 ,  A61K39/00 ,  A61K47/68 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10

Abstract: Provided are an anti-βKlotho antibody and the use thereof. The anti-βKlotho antibody can be used for treating βKlotho-mediated or βKlotho-FGFR1c-FGF21-mediated diseases, especially abnormal metabolic diseases, such as type 1 diabetes, type 2 diabetes, dyslipidemia, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, metabolic syndrome or obesity.

公开(公告)号：US20240092897A1

公开(公告)日：2024-03-21

申请号：US18035708

申请日：2021-11-04

Applicant: SHANGHAI JMT-BIO TECHNOLOGY CO., LTD.

Inventor： Ke HE ,  Shihua LIAO ,  Xu FENG ,  Baolan REN ,  Yuhan DU ,  Yingjiao CHEN ,  Liping SONG ,  Yi FAN

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention relates to the field of bio-pharmaceuticals and, in particular, to an anti-Siglec-15 antibody or an antigen binding fragment thereof, a nucleic acid sequence encoding the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an expression vector containing the nucleic acid sequence, a host cell containing the expression vector, a composition or a bispecific antibody comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an immune conjugate comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof linked to a therapeutic agent, as well as use of the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof in the preparation of a medicament for treatment of cancer. The anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof can bind to Siglec-15 and be useful for treatment of Siglec-15 relevant diseases.

公开(公告)号：US20240368286A1

公开(公告)日：2024-11-07

申请号：US18574887

申请日：2022-06-29

Applicant: SHANGHAI JMT-BIO TECHNOLOGY CO., LTD.

Inventor： Qian LIU ,  Baolan REN ,  Xu FENG ,  Liping SONG ,  Yi FAN ,  Li YANG

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  A61P3/04

Abstract: An anti-GFRAL antibody and a use thereof. The anti-GFRAL antibody or an antigen-binding portion thereof can be used for treating or preventing GFRAL-mediated or GFRAL-RET-GDF15 signaling pathway-mediated diseases or abnormalities, particularly cachexia syndrome.