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公开(公告)号：US20240238271A1
公开(公告)日：2024-07-18
申请号：US18254171
申请日：2021-11-25
发明人： Huajun JIN , Zhou HE , Tiantian LI , Yongchao SHEN , Haibin CHEN , Chen HUANG
IPC分类号： A61K31/4706 , A61K9/00 , A61K45/06 , A61P35/00
CPC分类号： A61K31/4706 , A61K9/0019 , A61K45/06 , A61P35/00
摘要： A pharmaceutical composition, containing chloroquine or a derivative thereof and a tumor cell killing agent, and a pharmaceutically acceptable excipient. Also provided is a use of chloroquine or a derivative thereof in preparation of a medication for treating a tumor.
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公开(公告)号：US20240325538A1
公开(公告)日：2024-10-03
申请号：US18254167
申请日：2021-11-25
发明人： Huajun JIN , Zhou HE , Tiantian LI , Yongchao SHEN , Haibin CHEN , Chen HUANG , Fuhui XU
IPC分类号： A61K39/00 , A61P35/00 , C12N5/0783
CPC分类号： A61K39/464499 , A61K39/4611 , A61P35/00 , C12N5/0636 , C12N2501/22 , C12N2501/2301 , C12N2501/2302 , C12N2501/2304 , C12N2501/2306 , C12N2501/2307 , C12N2501/2309 , C12N2501/231 , C12N2501/2312 , C12N2501/2315 , C12N2501/2318 , C12N2501/2321 , C12N2501/24 , C12N2501/515 , C12N2501/52 , C12N2502/30
摘要： A culture composition for expanding a TIL, containing IL-2, IL-7, IL-15, and an immune checkpoint antibody or an antigen-binding fragment thereof. The immune checkpoint antibody comprises any one or more of a PD-1 antibody, a CTLA-4 antibody, a LAG-3 antibody, a TIM-3 antibody, a TIGIT antibody, and a BTLA antibody. The present invention further relates to a TIL expanding culture medium, a method for preparing a TIL population, and a pharmaceutical composition. In the culture composition, cell proliferation and activity are ensured while greatly reducing the used amount of IL-2, and IL-2 treatment is removed after infusing the TILs obtained using the culture composition into a patient so as to reduce side effects; moreover, no feeder cells are used in an expansion process, exogenous pollution is reduced and the manufacturing process is simplified, the manufacturing costs reduced, and the manufacturing time shortened.
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