公开(公告)号：US20190169147A1

公开(公告)日：2019-06-06

申请号：US16086615

申请日：2017-03-28

申请人： SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD Wang, Yijin

发明人： Yunfei LI ,  Xiaoer XIA ,  Xin XU ,  Zhen ZHANG ,  Lei LIU ,  Xiaojuan ZHANG ,  Liming ZHANG ,  Dongsheng LI ,  Yijin WANG ,  Jian GE

IPC分类号： C07D295/096

摘要： The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present application provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present application prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.