公开(公告)号：US20230302132A1

公开(公告)日：2023-09-28

申请号：US18041536

申请日：2020-08-14

申请人： SHANGHAI XINGHUA BIO PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD

发明人： Hua LIU

IPC分类号： A61K39/00 ,  C07K14/42 ,  A61K39/39 ,  C07K14/55 ,  C12N5/0783

CPC分类号： A61K39/4611 ,  A61K39/4635 ,  A61K39/4637 ,  C07K14/42 ,  A61K39/39 ,  C07K14/55 ,  C12N5/0638 ,  A61K2239/39 ,  C12N2501/2302 ,  C12N2501/24 ,  C12N2501/59

摘要： Provided are a simple and convenient method for preparing universal immune cells and the use thereof. The method comprises placing allogeneic immune cells and specific cell mitogens, cytokines, and immunologic adjuvants in a liquid cell culture medium to be co-cultured in a culture container, so as to obtain a universal immune cell culture with a high immunocompetence. Many clinical long-term practical applications have proven that the universal immune cells are safe and reliable, durable and effective, and have no rejection reaction. Therefore, the universal immune cells can be used as maternal cells of other types of universal immune cell preparations, such as CAR-T and TCR-T, and can be used in fields including adoptive cellular immunotherapy, etc.