公开(公告)号：US20250092142A1

公开(公告)日：2025-03-20

申请号：US18470595

申请日：2023-09-20

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Fei XU ,  Lu XU ,  Tingting WU

IPC: C07K16/28 ,  A61K47/68 ,  C07K14/725 ,  C12N15/85

Abstract: The present disclosure discloses a monoclonal antibody targeting FZD7, preparation method and use thereof. The monoclonal antibody targeting FZD7 comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises an amino acid sequence of SEQ ID NO: 1 or an amino acid sequence with at least 99% sequence identity to sequence of SEQ ID NO: 1, the light chain variable region comprises an amino acid sequence of SEQ ID NO: 2 or an amino acid sequence having at least 99% sequence identity to sequence of SEQ ID NO: 2. The monoclonal antibody targeting FZD7 obtained by the present disclosure binds to the FZD7 protein both in vitro and in vivo and has clinical development value.