公开(公告)号：US20220257776A1

公开(公告)日：2022-08-18

申请号：US17618685

申请日：2020-06-11

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Xiaobao YANG ,  Biao JIANG ,  Xiaoling SONG ,  Ning SUN ,  Chaowei REN ,  Ying KONG ,  Jianshui ZHANG ,  Jinju CHEN ,  Yan LI ,  Yuedong ZHOU

IPC: A61K47/55 ,  A61K47/54 ,  A61P35/00

Abstract: A compound of general formula (I), a compound of general formula (III) and anti-tumor applications thereof. A series of compounds designed and synthesized have a wide range of pharmacological activities, have the function of degrading specific proteins and/or inhibiting activity, and can be used in related tumor and cancer treatments.

公开(公告)号：US20220313829A1

公开(公告)日：2022-10-06

申请号：US17632612

申请日：2020-08-05

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Xiaobao YANG ,  Biao JIANG ,  Xiaoling SONG ,  Ning SUN ,  Chaowei REN ,  Renhong SUN ,  Xiaojuan QU ,  Haixia LIU ,  Xing QIU

IPC: A61K47/55 ,  A61K47/54 ,  A61P35/00

Abstract: A bifunctional compound, or a pharmaceutically acceptable salt, an isomer, a prodrug, a polymorphic substance or a solvate thereof. The chemical structural formula of the bifunctional compound is represented as formula I, and the bifunctional compound can be used for preventing or treating cancers.