公开(公告)号：US11464765B2

公开(公告)日：2022-10-11

申请号：US17402006

申请日：2021-08-13

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Haitao Yang ,  Zhenming Jin ,  Xiuna Yang ,  Yao Zhao ,  Zihe Rao

IPC: A61K31/41 ,  A61K31/4439 ,  A61P31/14

Abstract: Disclosed is a use of an N-substituted pyridyl benzisoselazolone compound. The use is particularly a use in the preparation of a medicament for treating and/or preventing a disease caused by coronavirus. The present disclosure surprisingly found that the N-substituted pyridyl benzisoselazolone compound, such as ebselen, can significantly inhibit the activity of the main protease of a coronavirus and the intracellular replication capability of SARS-CoV-2, which can be used for treating a disease caused by coronavirus.