公开(公告)号：US20190133968A1

公开(公告)日：2019-05-09

申请号：US16097348

申请日：2017-04-27

申请人： SHANXI MEDICAL UNIVERSITY ,  SHANXI MEDICAL UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

发明人： Qingshan Li ,  Xiue Feng ,  Yuanlin Zhang ,  Lingge Han ,  Rongrong Chang

IPC分类号： A61K31/12 ,  A61K31/5377 ,  A61P13/12

摘要： Medical applications of 2,5′-dibromo-4,5,2′-trihydroxyldiphenylmethanone and 4,5,2′-tris(4-morpholinemethanoyl)-2,5′-dichlorobenzophenone are provided, particularly applications in preparation of drugs respectively for resisting type II diabetic nephropathy and for treating acute pyelonephritis and chronic nephritis. Moreover, two drugs respectively with the above two compounds as the active ingredient are provided, respectively for resisting the type II diabetic nephropathy and for treating the acute pyelonephritis and the chronic nephritis. Both of the two compounds are able to effectively improve renal functions of model rats suffered from the type II diabetic nephropathy, the acute pyelonephritis, and the chronic nephritis, showing an important application prospect in resisting the diabetic nephropathy and treating the acute pyelonephritis and the chronic nephritis.