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公开(公告)号：US20230322837A1
公开(公告)日：2023-10-12
申请号：US18323272
申请日：2023-05-24
发明人： Jun XU , Mengjiao HAO , Yuting ZHANG , Hao CHEN
IPC分类号： C07H13/08 , C07D311/36 , A61P31/14 , C07C69/88
CPC分类号： C07H13/08 , A61P31/14 , C07C69/88 , C07D311/36
摘要： Provided are stellate compounds that target spike proteins and have a significant anti-SARS-CoV-2 ability and a certain broad spectrum. Such molecules and salts thereof have at least one basic unit R(X)n, which binds at an orthotopic binding site such as an MD domain or an allosteric site, to a virus containing spike proteins or a virus having spike proteins on its surface, thereby preventing coronavirus or other viruses which express spike proteins on their surfaces from invading host cells, and preventing the occurrence of viral infection. In addition, interaction of the molecules and salts thereof with vitamin K-dependent proteins in the human body inhibits the expression of vitamin K so as to inhibit blood coagulation in the human body, thereby treating thrombosis caused by coronavirus and producing a curative effect for pneumonia caused by a severe viral infection.
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公开(公告)号：US20220135579A1
公开(公告)日：2022-05-05
申请号：US17577018
申请日：2022-01-17
发明人： Ziyang CHEN , Qiong GU , Hao CHEN , Jun XU
IPC分类号： C07D487/10 , A61K31/407 , A61P3/06 , A61K45/06
摘要： Provided is a liver X receptor regulator of spiro(3,3′-isopropylpyrrolidine oxindole), as well as a preparation method and use thereof. Specifically, a compound is provided, which is a compound represented by Formula (I); or a stereoisomer, geometric isomer, tautomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt, or prodrug of the compound represented by Formula (I).
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公开(公告)号：US20220153688A1
公开(公告)日：2022-05-19
申请号：US17562040
申请日：2021-12-27
发明人： Dane HUANG , Chao ZHAO , Qiong GU , Jun XU
IPC分类号： C07C251/76 , C07D213/80 , C07D213/84 , C07D213/75 , C07D217/06 , C07D277/56 , C07D277/82 , C07D295/185 , C07D211/58 , A61P19/10 , C07D417/12
摘要： Provided are a new class of hydrazone amide derivatives and the use thereof in the preparation of anti-osteoporosis drugs, wherein the structural formula of the hydrazone amide derivative is as shown in formula (I), and same are a new class of compounds with an anti-osteoporosis effect.
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公开(公告)号：US20220153713A1
公开(公告)日：2022-05-19
申请号：US17562976
申请日：2021-12-27
发明人： Dane HUANG , Chao ZHAO , Qiong GU , Jun XU
IPC分类号： C07D277/56 , A61P17/14 , C07D277/82 , C07C251/76 , C07D213/75 , C07D213/85 , C07D211/58 , C07D217/06 , C07D295/185
摘要： The present disclosure provides a brand-new hydrazone amide derivative and an application thereof in preparation of medicaments for preventing and treating alopecia. The structural formula of the hydrazone amide derivative is shown in formula (I), and the hydrazone amide derivative is a brand-new compound for stimulating hair follicle growth and preventing and treating alopecia.
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