公开(公告)号：US20240181080A1

公开(公告)日：2024-06-06

申请号：US18434358

申请日：2024-02-06

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

Inventor： Yingzi ZHAO ,  Botai LI ,  Dashuang GAO ,  Fan YANG

IPC: A61K48/00 ,  A61K31/5513 ,  A61K38/17 ,  A61P19/08 ,  C12N15/86

CPC classification number: A61K48/005 ,  A61K31/5513 ,  A61K38/177 ,  A61P19/08 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2750/14143

Abstract: Disclosed in the present invention is A method for controlling heterogeneity of vascular endothelial cells by utilizing sympathetic nerves is provided, comprising expressing an artificial designer protein receptor exclusively activated by a designer drug in neuron cells, and then activating the artificial designer protein receptor by the designer drug, thereby activating or inhibiting neuronal activity to achieve control of the heterogeneity of the vascular endothelial cells. The method enables local modulation of the sympathetic nervous activity, thereby controlling the heterogeneity of the vascular endothelial cells, and can achieve bidirectional modulation. According to the present invention, the heterogeneity of bone vascular endothelial cells is controlled by manipulating the sympathetic nerves, such that the subtype of the bone vascular endothelial cells is controlled, thereby affecting the bone mineral density coupled therewith. The present invention has important clinical significance in the field of treatment or prevention of osteoporosis.