公开(公告)号：US20240369583A1

公开(公告)日：2024-11-07

申请号：US18689508

申请日：2021-09-16

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

Inventor： Yu CHEN ,  Yijing CHEN ,  Yingying FAN

IPC: G01N33/92 ,  G01N30/02 ,  G01N30/72 ,  G01N30/88

Abstract: An Alzheimer's disease biomarker, and a screening method therefor and use thereof. The Alzheimer's disease biomarker is 11(Z), 14(Z)-eicosadienoic acid. The screening method for the Alzheimer's disease biomarker comprises: acquiring samples, testing the samples, and performing structural identification and data analysis on metabolites in the samples, wherein specifically, metabolites in faeces samples can be tested by liquid chromatography-mass spectrometry, to carry out structural identification on the metabolites; and selecting a metabolite showing a difference from the metabolite level of a control group as the Alzheimer's disease biomarker. Using 11(Z), 14(Z)-eicosadienoic acid as an Alzheimer's disease biomarker is of great significance to clinical early diagnosis of Alzheimer's disease; the present invention can be used for preparing a diagnostic tool for Alzheimer's disease, predicting the individual treatment effects of patients with Alzheimer's disease, and preparing drugs for treating Alzheimer's disease.