公开(公告)号：US20160003830A1

公开(公告)日：2016-01-07

申请号：US14852308

申请日：2015-09-11

申请人： SHIMADZU CORPORATION ,  OSAKA UNIVERSITY

发明人： Makoto Watanabe ,  Eiichi Matsuo ,  Naoki Kaneko ,  Toshiya Matsubara ,  Osamu Nishimura ,  Masaki Mori ,  Hideo Matsuda ,  Shigeto Seno ,  Ichiro Takemasa

IPC分类号： G01N33/574

CPC分类号： G01N33/57419 ,  G01N33/6893

摘要： The present invention provides a specific combination of colon cancer markers based on statistical knowledge, which is capable of detecting a larger number of colon cancer patients in an earlier stage while maintaining high specificity. A multiplex colon cancer marker panel comprising a combination of five colon cancer markers of Carcinoembryonic antigen-related cell adhesion molecule 5, Carbohydrate antigen 19-9, Galectin-4, APEX nuclease and Actin-related protein 2. A method for analyzing colon cancer markers using multiplex colon cancer marker panel.

公开(公告)号：US10809262B2

公开(公告)日：2020-10-20

申请号：US14852308

申请日：2015-09-11

申请人： SHIMADZU CORPORATION ,  OSAKA UNIVERSITY

发明人： Makoto Watanabe ,  Eiichi Matsuo ,  Naoki Kaneko ,  Toshiya Matsubara ,  Osamu Nishimura ,  Masaki Mori ,  Hideo Matsuda ,  Shigeto Seno ,  Ichiro Takemasa

IPC分类号： G01N33/574 ,  G01N33/68

摘要： The present invention provides a specific combination of colon cancer markers based on statistical knowledge, which is capable of detecting a larger number of colon cancer patients in an earlier stage while maintaining high specificity. A multiplex colon cancer marker panel comprising a combination of five colon cancer markers of Carcinoembryonic antigen-related cell adhesion molecule 5, Carbohydrate antigen 19-9, Galectin-4, APEX nuclease and Actin-related protein 2. A method for analyzing colon cancer markers using multiplex colon cancer marker panel.

公开(公告)号：US20130165340A1

公开(公告)日：2013-06-27

申请号：US13723133

申请日：2012-12-20

申请人： SHIMADZU CORPORATION ,  OSAKA UNIVERSITY

发明人： Makoto Watanabe ,  Eiichi Matsuo ,  Naoki Kaneko ,  Toshiya Matsubara ,  Osamu Nishimura ,  Masaki Mori ,  Hideo Matsuda ,  Shigeto Seno ,  Ichiro Takemasa

IPC分类号： G01N33/68

CPC分类号： G01N33/57419 ,  G01N33/6893

摘要： The present invention provides a specific combination of colon cancer markers based on statistical knowledge, which is capable of detecting a larger number of colon cancer patients in an earlier stage while maintaining high specificity. A multiplex colon cancer marker panel comprising a combination of five colon cancer markers of Carcinoembryonic antigen-related cell adhesion molecule 5, Carbohydrate antigen 19-9, Galectin-4, APEX nuclease and Actin-related protein 2.A method for analyzing colon cancer markers using multiplex colon cancer marker panel.

摘要翻译： 本发明提供了基于统计知识的结肠癌标志物的特异性组合，其能够在保持高特异性的同时检测较早数量的结肠癌患者。 包括癌胚抗原相关细胞粘附分子5，碳水化合物抗原19-9，半乳凝素-4，APEX核酸酶和肌动蛋白相关蛋白2的五个结肠癌标志物的组合的多重结肠癌标志物。2.一种分析结肠癌标志物的方法 使用多重结肠癌标记物。