公开(公告)号：US20140178467A1

公开(公告)日：2014-06-26

申请号：US14193543

申请日：2014-02-28

申请人： SHIRE LLC

发明人： Roger Withington ,  David Pierce ,  Josephine Christine Ferdinando ,  Peter Neil Davies

IPC分类号： A61K9/48 ,  A61K33/24

CPC分类号： A61K33/24 ,  A61K9/14 ,  A61K9/48 ,  A61K9/4825 ,  A61K9/4858 ,  A61K47/02 ,  A61K47/36

摘要： The present invention includes an oral pharmaceutical capsule comprising a shell, lanthanum carbonate or lanthanum carbonate hydrate, and a lubricant such as talc, wherein the shell encapsulates the lanthanum carbonate or its hydrate and the lubricant. Capsule shells comprise, for example, gelatin. The present invention also includes an oral pharmaceutical powder comprising lanthanum carbonate or lanthanum carbonate hydrate and a pharmaceutically acceptable excipient. The oral pharmaceutical capsules and powders of the present invention can be administered to treat a patient at risk of or suffering from hyperphosphatemia, at risk of or suffering from chronic kidney disease (CKD), at risk of or suffering from soft tissue calcification associated with CKD, or at risk of or suffering from secondary hyperparathyroidism.

摘要翻译： 本发明包括包含壳，碳酸镧或碳酸镧水合物的口服药物胶囊和滑石等润滑剂，其中所述壳包裹碳酸镧或其水合物和润滑剂。 胶囊壳包括例如明胶。 本发明还包括含有碳酸镧或碳酸镧水合物和药学上可接受的赋形剂的口服药物粉末。 可以施用本发明的口服药物胶囊和粉末以治疗处于或患有高血磷症的患者，患有或患有与CKD相关的软组织钙化的风险或患有慢性肾脏疾病（CKD）的风险 ，或患有继发性甲状旁腺功能亢进的风险。