公开(公告)号：US20220332725A1

公开(公告)日：2022-10-20

申请号：US17023266

申请日：2020-09-16

Applicant: SHY Therapeutics LLC

Inventor： Yaron R. Hadari ,  Luca Carta ,  Michael Schmertzler ,  Theresa M. Williams ,  Charles H. Reynolds

IPC: C07D495/04 ,  C07D473/30 ,  C07D413/14 ,  C07D239/94 ,  C07D401/14 ,  C07D495/14 ,  C07D401/12 ,  C07D401/04 ,  C07D271/06 ,  C07D487/04 ,  C07D265/30 ,  C07D417/14 ,  C07D221/04 ,  C07D407/14 ,  C07D409/14 ,  C07D471/04

Abstract: Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.

公开(公告)号：US10588894B2

公开(公告)日：2020-03-17

申请号：US16013872

申请日：2018-06-20

Applicant: SHY Therapeutics LLC

Inventor： Yaron R. Hadari ,  Luca Carta ,  Michael Schmertzler ,  Theresa M. Williams ,  Charles H. Reynolds ,  Rebecca Hutcheson

IPC: A61K31/4365 ,  C07D495/04 ,  A61P29/00 ,  A61P35/00 ,  A61P25/28 ,  A61K31/505 ,  C12N15/10

Abstract: Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.

公开(公告)号：US20240360141A1

公开(公告)日：2024-10-31

申请号：US18626740

申请日：2024-04-04

Applicant: SHY Therapeutics, LLC

Inventor： Yaron R. Hadari ,  Michael Schmertzler ,  Theresa M. Williams ,  Carolina Bigarella ,  Luca Carta ,  Rebecca Hutcheson ,  Sufang Zhang ,  Charles H. Reynolds

IPC: C07D487/04 ,  A61K31/53 ,  A61P35/00

CPC classification number: C07D487/04 ,  A61K31/53 ,  A61P35/00

Abstract: Provided herein are compounds of Formula I, or a pharmaceutically acceptable form thereof, and pharmaceutical compositions comprising the same. Also provided herein methods of modulating the activity of cellular targets by administering to a subject a compound of Formula I, or a pharmaceutically acceptable form thereof. Further provided herein are methods of treating cancer, fibrotic diseases, and inflammatory diseases by administering to a subject a compound of or a pharmaceutically acceptable form thereof.

公开(公告)号：US11541041B1

公开(公告)日：2023-01-03

申请号：US17373450

申请日：2021-07-12

Applicant: Shy Therapeutics LLC

Inventor： Yaron R. Hadari ,  Luca Carta ,  Michael Schmertzler ,  Theresa M. Williams ,  Charles H. Reynolds ,  Rebecca Hutcheson

IPC: A61K31/4365 ,  C12N15/10 ,  A61P35/00 ,  A61P29/00 ,  C07K14/435 ,  C07D495/04 ,  A61K31/505 ,  A61P25/28

Abstract: Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.

公开(公告)号：US11026930B1

公开(公告)日：2021-06-08

申请号：US16847467

申请日：2020-04-13

Applicant: Shy Therapeutics LLC

Inventor： Yaron R. Hadari ,  Luca Carta ,  Michael Schmertzler ,  Theresa M. Williams ,  Charles H. Reynolds ,  Rebecca Hutcheson

IPC: C12N15/10 ,  A61K31/4365 ,  A61P25/28 ,  C07D495/04 ,  A61P29/00 ,  A61P35/00 ,  A61K31/505

Abstract: Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.

公开(公告)号：US10940139B2

公开(公告)日：2021-03-09

申请号：US16654934

申请日：2019-10-16

Applicant: Shy Therapeutics LLC

Inventor： Yaron R. Hadari ,  Luca Carta ,  Michael Schmertzler ,  Theresa M. Williams ,  Charles H. Reynolds ,  Rebecca Hutcheson

IPC: A61K31/4365 ,  A61P29/00 ,  A61P35/00 ,  A61P25/28 ,  C07D495/04 ,  A61K31/505 ,  C12N15/10

Abstract: Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.

公开(公告)号：US11560390B2

公开(公告)日：2023-01-24

申请号：US17023266

申请日：2020-09-16

Applicant: SHY Therapeutics LLC

Inventor： Yaron R. Hadari ,  Luca Carta ,  Michael Schmertzler ,  Theresa M. Williams ,  Charles H. Reynolds

IPC: C07D401/04 ,  C07D401/14 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/44 ,  A61P29/00 ,  A61P35/00 ,  C07D495/04 ,  C07D495/14 ,  C07D471/04 ,  C07D413/14 ,  C07D221/04 ,  C07D401/12 ,  C07D407/14 ,  C07D409/14 ,  C07D239/94 ,  C07D417/14 ,  C07D487/04 ,  C07D265/30 ,  C07D271/06 ,  C07D473/30

Abstract: Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.

公开(公告)号：US20220347162A1

公开(公告)日：2022-11-03

申请号：US17143084

申请日：2021-01-06

Applicant: Shy Therapeutics LLC

Inventor： Yaron R. Hadari ,  Luca Carta ,  Michael Schmertzler ,  Theresa M. Williams ,  Charles H. Reynolds ,  Rebecca Hutcheson

IPC: A61K31/4365 ,  A61P25/28 ,  C07D495/04 ,  A61P29/00 ,  C12N15/10 ,  A61P35/00 ,  A61K31/505

Abstract: Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.

公开(公告)号：US11000515B2

公开(公告)日：2021-05-11

申请号：US16654800

申请日：2019-10-16

Applicant: Shy Therapeutics LLC

Inventor： Yaron R. Hadari ,  Luca Carta ,  Michael Schmertzler ,  Theresa M. Williams ,  Charles H. Reynolds ,  Rebecca Hutcheson

IPC: C07D495/04 ,  A61K31/4365 ,  A61P29/00 ,  A61P35/00 ,  A61P25/28 ,  A61K31/505 ,  C12N15/10

Abstract: Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.

公开(公告)号：US10933054B2

公开(公告)日：2021-03-02

申请号：US16654844

申请日：2019-10-16

Applicant: Shy Therapeutics LLC

Inventor： Yaron R. Hadari ,  Luca Carta ,  Michael Schmertzler ,  Theresa M. Williams ,  Charles H. Reynolds ,  Rebecca Hutcheson

IPC: C07D495/04 ,  A61K31/4365 ,  A61P29/00 ,  A61P35/00 ,  A61P25/28 ,  A61K31/505 ,  C12N15/10

Abstract: Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.