专利检索 ap:("SITEONE THERAPEUTICS, INC." OR "THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY") AND inv:"Matthew Axtman" 第 1 页

1.

发明授权
10′,11′-modified saxitoxins useful for the treatment of pain 有权

公开(公告)号：US10106549B2

公开(公告)日：2018-10-23

申请号：US15302964

申请日：2015-04-09

申请人： SITEONE THERAPEUTICS, INC. , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Hassan Pajouhesh , George Miljanich , John Mulcahy , Justin Du Bois , Matthew Axtman , James Walker , Jeffrey E. Merit

IPC分类号： C07D487/14

摘要： Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function, for example conditions associated with pain. The compounds are 10′,11′-modified saxitoxins. The compounds are optionally additionally modified at carbon 13. In certain embodiments, the 10′,11′-modified saxitoxins are of Formula I: where R1, R2 and R3 are as described herein. Also provided herein are methods of treating pain in a mammal comprising administering an effective treatment amount of a 10′,11′ modified saxitoxin or composition to a mammal. In an embodiment, the mammal is a human.