公开(公告)号：US20210212962A1

公开(公告)日：2021-07-15

申请号：US17147602

申请日：2021-01-13

Applicant: Sol-Gel Technologies Ltd.

Inventor： Marcel Zighelboim ,  Hila Hakak Djerbi ,  Karine Neimann

IPC: A61K31/05 ,  A61K31/44 ,  A61K9/00 ,  A61K9/06 ,  A61P17/00

Abstract: The present invention, in some embodiments thereof, relates to topical compositions and methods of treatment, prevention and/or amelioration of granuloma annulare, a non-infection granulomatous disease, or a subcutaneous inflammation by topical or intralesional administration of compositions comprising tapinarof.

公开(公告)号：US20210315834A1

公开(公告)日：2021-10-14

申请号：US17227459

申请日：2021-04-12

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ori Nov ,  Marcel Zighelboim ,  Karine Neimann

IPC: A61K31/05 ,  A61K45/06 ,  A61K9/00 ,  A61K31/517 ,  A61K31/4174 ,  A61K9/06

Abstract: The present invention is directed to a composition comprising aryl hydrocarbon receptor (AhR) agonists and combinations for the prevention and treatment of alopecia and hair loss, e.g. when such conditions are caused by chemotherapy, radiation therapy or hormone replacement therapy.

公开(公告)号：US11633399B2

公开(公告)日：2023-04-25

申请号：US16737503

申请日：2020-01-08

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Moshe Arkin ,  Marcel Zighelboim ,  Ori Nov ,  Ofer Toledano ,  Karine Neimann

IPC: A61K31/505 ,  A61K31/517 ,  A61K31/5377 ,  A61K39/395 ,  A61K9/00 ,  A61K45/06 ,  A61K31/05 ,  A61K9/06 ,  A61K31/506

Abstract: This invention relates to compositions and methods of treatment of skin or mucosal disorders by administration of compositions comprising at least one EGFR inhibitor, such as topical compositions comprising erlotinib. The compositions of this invention are useful for the treatment, prevention or amelioration of skin or mucosal disorders like psoriasis, palmoplantar psoriasis, acquired palmoplantar keratosis, eczema, ichtyosis vulgaris, non-melanoma skin cancer, actinic keratosis, a keratinization skin disorder, a keratinization mucosal disorder, pachyonychia congenita, hidradenitis suppurativa, Gorlin syndrome, prurigo nodularis and prurigo pigmentosa.

公开(公告)号：US20210236432A1

公开(公告)日：2021-08-05

申请号：US17166336

申请日：2021-02-03

Applicant: Sol-Gel Technologies Ltd.

Inventor： Moshe Arkin ,  Marcel Zighelboim ,  Karine Neimann ,  Hila Hakak Djerbi

IPC: A61K9/50 ,  A61K31/44 ,  A61K9/06

Abstract: Provided herein is a topical composition comprising roflumilast, roflumilast N-oxide or salts thereof as an active agent. The active agent in the composition of this invention is in encapsulated or non-encapsulated form, according to need.
The above composition is useful for the treatment, prevention or alleviation of a skin disorder selected from Hidradenitis suppurativa and Prurigo nodularis.