公开(公告)号：US20220315533A1

公开(公告)日：2022-10-06

申请号：US17613472

申请日：2020-10-26

申请人： SOOCHOW UNIVERSITY

发明人： Xiaoping XU ,  Shunjun JI ,  Ruiying ZHANG

IPC分类号： C07D209/96

摘要： The present invention provides a method for synthesizing a 3-spiro three-membered ring indolinone derivative, which comprises under a protective atmosphere, reacting a 3-indol-ethanol compound as a reaction raw material at 20-60° C. in the presence of an additive and an organic base in an organic solvent, to obtain a 3-spiro three-membered ring indolinone compound after the reaction is complete. The additive is N-bromosuccinimide (NBS) or N-chlorosuccinimide (NCS). The method of the present invention does not require a metal catalyst, and the 3-spiro three-membered ring indolinone derivative is synthesized in one step in the presence of NBS or NCS. The reaction conditions are mild, the operations are simple and safe, and the yield is high.