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公开(公告)号：US20230143091A1
公开(公告)日：2023-05-11
申请号：US17620036
申请日：2020-06-19
发明人： Scott CROWE , Mike WEST , Kevin ROBERTS , Tim CARLTON , Luana MAGGIORE , Marion CUBITT , Lurdes DUARTE , Keith RAY
CPC分类号： C07K16/241 , C07K16/2866 , A61P1/00 , A61P29/00 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2319/50
摘要： There is provided inter alia a composition comprising a TNF-alpha binding polypeptide and an IL-7R binding polypeptide.
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公开(公告)号：US20230056445A1
公开(公告)日：2023-02-23
申请号：US17620030
申请日：2020-06-19
发明人： Scott CROWE , Mike WEST , Kevin ROBERTS , Tim CARLTON , Luana MAGGIORE , Marion CUBITT , Lurdes DUARTE , Martyn SYMMONS , Keith RAY
IPC分类号： C07K16/28
摘要： There are provided inter alia polypeptides capable of inhibiting IL-7 and/or L-TSLP binding to IL-7R (IL-7R), as well as to constructs and pharmaceutical compositions comprising these polypeptides.
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公开(公告)号：US20240277864A1
公开(公告)日：2024-08-22
申请号：US18307729
申请日：2023-04-26
发明人： Scott CROWE , Kevin ROBERTS , Tim CARLTON , Luana MAGGIORE , Marion CUBITT , Mike WEST , Keith RAY
CPC分类号： A61K47/6849 , A61K9/0053 , A61K47/65 , A61K47/6845 , A61P1/00 , C07K16/241 , C07K16/2866 , A61K2039/505 , A61K2039/507 , A61K2039/542 , C07K2317/21 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： There is provided inter alia a composition comprising a TNF-alpha binding polypeptide and an IL-6R binding polypeptide.
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公开(公告)号：US20230287098A1
公开(公告)日：2023-09-14
申请号：US18302721
申请日：2023-04-18
发明人： Scott CROWE , Mike WEST , Kevin ROBERTS , Tim CARLTON , Luana MAGGIORE , Marion CUBITT , Keith RAY
IPC分类号： C07K16/24 , A61K45/06 , A61K31/713 , A61K9/19 , A61K31/606 , A61K9/00 , A61K31/7088 , A61K38/00
CPC分类号： C07K16/241 , A61K45/06 , A61K31/713 , A61K9/19 , A61K31/606 , A61K9/0014 , A61K31/7088 , A61K38/00 , A61K2039/505
摘要： There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to TNF-alpha, wherein the immunoglobulin chain variable domain comprises three complementarity determining regions (CDR1-CDR3) and four framework regions (FR1-FR4), wherein CDR1-CDR3 and FR1-FR4 are as defined in the specification.
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公开(公告)号：US20220363769A1
公开(公告)日：2022-11-17
申请号：US17752710
申请日：2022-05-24
发明人： Scott CROWE , Mike WEST , Kevin ROBERTS , Tim CARLTON , Luana MAGGIORE , Marion CUBITT , Lurdes DUARTE , Martyn SYMMONS , Keith RAY
IPC分类号： C07K16/28
摘要： There are provided inter alia polypeptides capable of inhibiting IL-7 and/or L-TSLP binding to IL-7R (IL-7R), as well as to constructs and pharmaceutical compositions comprising these polypeptides.
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