公开(公告)号：US3798320A

公开(公告)日：1974-03-19

申请号：US3798320D

申请日：1971-09-09

Applicant: SOUTH AFRICAN INVENTIONS

Inventor： WEISS K ,  CAMERON C

IPC: A61K39/00 ,  C12N1/02 ,  C12K1/00

CPC classification number: C12N1/02 ,  A61K39/00 ,  Y10S435/803 ,  Y10S435/822 ,  Y10S435/842 ,  Y10S435/879

Abstract: BACTERIA ARE RENDERED INDISPERSABLE IN AQUEOUS MEDIUM, E.G. AQUEOUS CULTURE FLUID BY MEANS OF A LINEAR FILAMENTARY NON-CHARGED POLYMER PERCIPITANT, PREFERABLY A POLYALKYLENE GLYCOL SUCH AS PEG WITHIN THE PREFERRED MOLECULAR WEIGHT RANGE OF 2,000 TO 3,000. THE INVENTION CAN BE APPLIED TO A WIDE RANGE OF APPLICATIONS IN THE FIELD OF IMMULOGY, PARTICULARLY IN THE MANUFACTURE OF VACCINES. BACTERIAL MATTER CAN BE CONCERNED AS A USEFUL PRODUCT OR REMOVED FROM OTHER SUBSTANCES, E.G. TOXINS TO PURIFY THE LATTER. THUS, I.A. NOVEL VACCINE AGAINST PULPY KIDNEY DISEASE IS PRODUCED, CONTAINING THE IMMUNOLOGICALLY VALUABLE TOXOIDS FREE OF BACTERIA CELLS.