公开(公告)号：US20250052684A1

公开(公告)日：2025-02-13

申请号：US18008575

申请日：2022-02-16

Applicant: SOUTHEAST UNIVERSITY

Inventor： Xiangwei ZHAO ,  Ruihua FEI

IPC: G01N21/65

Abstract: A nanotag includes a gold core, the gold core is sequentially coated with a silver shell and a gold shell, and a Raman dye is arranged between the silver shell and the gold shell; further it discloses a making method for a high-stability SERS nanotag that includes the following steps: a. adding tetrachloroauric acid into ultrapure water, after boiling, quickly adding trisodium citrate, continuously boiling for a few minutes, stopping heating, and cooling; b. adding hexadecyl trimethyl ammonium chloride (CTAC) into product obtained in the step a, stirring, and then adding ascorbic acid and AgNO3, and centrifugating and resuspending in the CTAC; c. adding CTAC into product obtained in the step b, stirring, adding a Raman dye, ascorbic acid and sodium hydroxide, injecting a mixture of tetrachloroauric acid and potassium iodide, and centrifuge the mixture and resuspending in the CTAC.