公开(公告)号：US11911536B2

公开(公告)日：2024-02-27

申请号：US17602202

申请日：2020-09-23

Applicant: SOUTHEAST UNIVERSITY

Inventor： Ning Gu ,  Xin Liu

IPC: A61L31/00 ,  A61L31/04 ,  B29C39/38 ,  B29L31/00

CPC classification number: A61L31/047 ,  B29C39/38 ,  B29K2089/00 ,  B29L2031/7542

Abstract: The present invention relates to a method for molding a self-supporting silk fibroin catheter stent, which comprises preparing an excellent catheter stent by a mold casting and freeze-drying molding process using silk fibroin as a raw material. The raw material is silk fibroin extracted from natural mulberry silk; and the mold is a hollow tubular mold, having an outer shell that is a transparent polyethylene straw with a diameter of 6 mm and an inner core that is a fiber rod FRP with a diameter of 3 mm, with the two ends being closed. The mold casting and freeze-drying molding process comprises the steps of casting; pre-freezing; removing the mold and placing the mold onto a pre-frozen freeze-drying plate; and freeze-drying. The freeze-drying procedure comprises: (1) a pre-freezing stage; (2) a freezing-vacuum transition stage; (3) a gradient temperature-rising and freeze-drying stage; and (4) a secondary freeze-drying stage. The freeze-drying procedure is strictly regulated in accordance with the specifications of freeze-dried stents. The prepared stent has a good shape, and good tolerance without adding any additional components. The stent presents a three-dimensional porous space structure, the process is simple, and the stent meets the requirements for tissue-engineered vascular stent in clinic.