公开(公告)号：US20200024365A1

公开(公告)日：2020-01-23

申请号：US16484977

申请日：2017-04-27

Applicant: SOUTHEAST UNIVERSITY

Inventor： Wei XIE ,  Rui HAO ,  Xuechen ZHOU ,  Yunyan ZHOU ,  Zhipeng SU

IPC: C07K16/40 ,  C12N15/88 ,  C12N15/85

Abstract: It relates to a nanobody encoded by a mRNA and an application thereof, and more particularly, to the field of nanobody drugs. In order to solve the problem above, the invention provides a novel concept and a method system for regulating an intracellular protein using an mRNA-encoding nanobody. The invention discloses a nanobody encoded by a mRNA, and encoding information carried by the mRNA is recognized, translated and expressed to a single-chain nanobody that can be bound to a targeting protein in a cell. By adopting the method, a function of a disease-related protein in a cell can be effectively and specifically interfered with, thus achieving the object of disease treatment.