公开(公告)号：US20240125791A1

公开(公告)日：2024-04-18

申请号：US18399973

申请日：2023-12-29

Applicant: SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Yi LI ,  Ronghui LIU ,  Yang FU

IPC: G01N33/68 ,  G01N33/543

CPC classification number: G01N33/6818 ,  G01N33/54373 ,  G01N33/6845

Abstract: A screening method for an amino acid sequence of a protein nanopore, a protein nanopore, and applications thereof. The screening method includes: evaluating a characteristic sequence of a dual-pore structure, using a model to search for an amino acid sequence matched with the characteristic feature of the dual-pore structure, removing a redundant candidate sequence and then performing positioning and screening, calculating the matching length and envelope length of the candidate sequence, then performing registration to obtain a relative mismatching relationship with a known protein nanopore, and performing analysis to obtain a final sequence.