公开(公告)号：US12290574B2

公开(公告)日：2025-05-06

申请号：US17250712

申请日：2019-08-23

Applicant: SPARK THERAPEUTICS, INC.

Inventor： Xavier Anguela ,  Liron Elkouby

IPC: A61K48/00 ,  A61K9/00 ,  A61P7/04 ,  C07K14/755 ,  C07K14/775 ,  C07K14/81 ,  C12N7/00 ,  C12N15/86 ,  A61K38/00

Abstract: The disclosure includes CpG reduced regulatory elements, polynucleotides comprising such CpG reduced regulatory elements, expression cassettes comprising such CpG reduced regulatory elements, and recombinant AAV vectors comprising such CpG reduced regulatory elements. The regulatory elements can be, for example, operably coupled to a transgene.