公开(公告)号：US20170137524A1

公开(公告)日：2017-05-18

申请号：US15361839

申请日：2016-11-28

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Dario A. A. Vignali ,  Seng-ryong Woo ,  Greg M. Delgoffe

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0387 ,  A61K31/713 ,  A61K38/1709 ,  A61K39/0011 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/5158 ,  C07K16/2803 ,  C07K2317/32 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C12N5/0637 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2501/165

Abstract: The invention is directed to treatment of cancer, infections and various inflammatory and autoimmune conditions by affecting regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis.

公开(公告)号：US20200010552A1

公开(公告)日：2020-01-09

申请号：US16438696

申请日：2019-06-12

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Dario A. A. Vignali ,  Seng-Ryong Woo ,  Greg M. Delgoffe

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  A61K39/00 ,  C12N5/0783 ,  A61K31/713 ,  A61K38/17 ,  C12N15/113

Abstract: The invention is directed to treatment of cancer, infections and various inflammatory and autoimmune conditions by affecting regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis.

公开(公告)号：US20150266959A1

公开(公告)日：2015-09-24

申请号：US14434129

申请日：2013-10-08

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Dario A. A. Vignali ,  Seng-ryong Woo ,  Greg M. Delgoffe

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0387 ,  A61K31/713 ,  A61K38/1709 ,  A61K39/0011 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/5158 ,  C07K16/2803 ,  C07K2317/32 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C12N5/0637 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2501/165

Abstract: The invention is directed to treatment of cancer, infections and various inflammatory and autoimmune conditions by affecting regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis. The present invention satisfies this and other needs by demonstrating that the regulatory T cell (Treg)-restricted neuropilin-1 (Nrp 1) interacts with the cell surface ligand semaphorin-4a (Sema4a) (e.g., on conventional T cells (Tconv), conventional dendritic cells (cDCs), and/or plasmacytoid dendritic cells (pDCs)) to potentiate reg function and enhance their survival at inflammatory sites.

Abstract translation: 本发明涉及通过经由Neuropilin-1：信号素轴影响调节性T细胞稳定性和功能来治疗癌症，感染和各种炎症和自身免疫病症。 本发明通过证明调节性T细胞（Treg） - 限制性神经蛋白-1（Nrp 1）与细胞表面配体信号素-4a（Sema4a）（例如，常规T细胞（Tconv））相互作用来满足这一点和其他需要， 常规树突状细胞（cDC）和/或浆细胞样树突状细胞（pDC））以增强寄生虫功能并增强其在炎症部位的存活。

公开(公告)号：US09540439B2

公开(公告)日：2017-01-10

申请号：US14434129

申请日：2013-10-08

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Dario A. A. Vignali ,  Seng-ryong Woo ,  Greg M. Delgoffe

IPC: A61K39/395 ,  C07K16/28 ,  A61K38/17 ,  A61K31/713 ,  C12N5/0783 ,  C12N15/113 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0387 ,  A61K31/713 ,  A61K38/1709 ,  A61K39/0011 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/5158 ,  C07K16/2803 ,  C07K2317/32 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C12N5/0637 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2501/165

Abstract: The invention is directed to treatment of cancer, infections and various inflammatory and autoimmune conditions by affecting regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis. The present invention satisfies this and other needs by demonstrating that the regulatory T cell (Treg)-restricted neuropilin-1 (Nrp 1) interacts with the cell surface ligand semaphorin-4a (Sema4a) (e.g., on conventional T cells (Tconv), conventional dendritic cells (cDCs), and/or plasmacytoid dendritic cells (pDCs)) to potentiate reg function and enhance their survival at inflammatory sites.

Abstract translation: 本发明涉及通过经由Neuropilin-1：信号素轴影响调节性T细胞稳定性和功能来治疗癌症，感染和各种炎症和自身免疫病症。 本发明通过证明调节性T细胞（Treg） - 限制性神经蛋白-1（Nrp 1）与细胞表面配体信号素-4a（Sema4a）（例如，常规T细胞（Tconv））相互作用来满足这一点和其他需要， 常规树突状细胞（cDC）和/或浆细胞样树突状细胞（pDC））以增强寄生虫功能并增强其在炎症部位的存活。