公开(公告)号：US10526380B2

公开(公告)日：2020-01-07

申请号：US15794503

申请日：2017-10-26

Applicant: St. Jude Children's Research Hospital

Inventor： Joseph Paul Taylor ,  Peipei Zhang

IPC: C12N15/82 ,  C07K14/415 ,  C12N9/14 ,  C12N13/00

Abstract: A nucleic acid molecule encoding a fusion protein composed of a plant cryptochrome at the amino terminus, and a GTPase-Activating Protein SH3 Domain-Binding Protein (G3BP) is provided for light-dependent, G3BP-mediated stress granule formation.

公开(公告)号：US20210179676A1

公开(公告)日：2021-06-17

申请号：US16758905

申请日：2018-10-26

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： J. Paul Taylor ,  Peipei Zhang

IPC: C07K14/415 ,  C12N9/14

Abstract: A nucleic acid molecule encoding a fusion protein composed of an inducible multimerization moiety at the amino terminus, and a GTPase-Activating Protein SH3 Domain-Binding Protein (G3BP) is provided for exogenous stimulus/G3BP-mediated stress granule formation. Further disclosed are chemical or light inducible multimerization proteins or protein domains that can be used for the nucleic acid molecule production, and a method of inducing stress granule formation in a cell comprising expressing the nucleic acid molecule.

公开(公告)号：US20190127428A1

公开(公告)日：2019-05-02

申请号：US15794503

申请日：2017-10-26

Applicant: St. Jude Children's Research Hospital

Inventor： Joseph Paul Taylor ,  Peipei Zhang

IPC: C07K14/415 ,  C12N9/14 ,  C12N13/00

CPC classification number: C07K14/415 ,  C07K2319/00 ,  C12N9/14 ,  C12N13/00 ,  C12Y306/04012 ,  C12Y306/04013

Abstract: A nucleic acid molecule encoding a fusion protein composed of a plant cryptochrome at the amino terminus, and a GTPase-Activating Protein SH3 Domain-Binding Protein (G3BP) is provided for light-dependent, G3BP-mediated stress granule formation.