公开(公告)号：US20250116673A1

公开(公告)日：2025-04-10

申请号：US18681966

申请日：2022-08-10

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Paul THOMAS ,  Mikhail POGORELYY ,  Anastasia MINERVINA

IPC: G01N33/68 ,  G01N33/50

Abstract: Disclosed are methods for identifying or determining whether a subject exhibits a CD4+ memory T cell response to SARS-CoV-2 infection or vaccination, assessing the efficacy of a SARS-CoV-2 vaccine, and developing personalized SARS-CoV-2 treatment plans by detecting the presence and/or quantity of a particular T cell receptor a chain that recognizes a specific Spike protein epitope.

公开(公告)号：US20250066852A1

公开(公告)日：2025-02-27

申请号：US18721777

申请日：2022-12-22

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Mikhail POGORELYY ,  Anastasia MINERVINA ,  Paul THOMAS

IPC: C12Q1/6876

Abstract: A kit and method for analyzing nucleic acid molecules encoding T cell receptor (TCR) chains from individual T cells are disclosed. In particular, a method for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding TCRs is provided.