公开(公告)号：US20230181762A1

公开(公告)日：2023-06-15

申请号：US17924469

申请日：2021-05-07

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Sheng ZHOU ,  Brian SORRENTINO ,  Yong CHENG

IPC: A61K48/00 ,  C12N15/86

CPC classification number: A61K48/0008 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2830/48 ,  C12N2830/40

Abstract: A construct including a genomic insulator element that exhibits strong enhancer blocking activities in T lymphocytes is provided as are host cells, pharmaceutical compositions and methods of using the construct in the treatment of disease, in particular a disease to be treated with a retroviral vector-modified T lymphocyte.