公开(公告)号：US20230312671A1

公开(公告)日：2023-10-05

申请号：US17919728

申请日：2021-04-23

Applicant: St. Jude Children's Research Hospital, Inc.

Inventor： Mireya Paulina VELASQUEZ ,  Stephen GOTTSCHALK ,  Nikhil HEBBAR ,  Rebecca EPPERLY ,  Abishek VAIDYA

IPC: C07K14/725 ,  A61P35/00 ,  C12N15/63

CPC classification number: C07K14/7051 ,  A61P35/00 ,  C12N15/63 ,  C07K2319/02 ,  C07K2319/03

Abstract: The present invention provides a chimeric antigen receptor (CAR) comprising an extracellular target-binding domain comprising at least one glucose-regulated-protein 78 (GRP78)-binding moiety. The present invention further provides polynucleotides and recombinant vectors encoding such CARs. The present invention further provides isolated host cells and methods for preparing isolated host cells expressing the CARs. The present invention further provides pharmaceutical compositions comprising the host cells and methods for treating a tumor using the pharmaceutical compositions.

公开(公告)号：US20220195007A1

公开(公告)日：2022-06-23

申请号：US17602892

申请日：2020-04-10

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Mireya Paulina VELASQUEZ ,  Stephen GOTTSCHALK ,  Janice RIBERDY ,  Albert ZHOU ,  Byoung RYU ,  Abishek VAIDYA ,  Giedre KRENCIUTE

IPC: C07K14/725 ,  A61P35/02 ,  C07K14/705 ,  C12N15/86 ,  C12N5/0783

Abstract: The present disclosure provides chimeric antigen receptors (CARs), particularly CARs that have enhanced antitumor properties and/or can be regulated by safety switches. Also provided are polypeptides of the CARs and other related molecules, polynucleotides, vectors, and cell compositions comprising the same. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a cancer in a subject are also provided.