公开(公告)号：US3905979A

公开(公告)日：1975-09-16

申请号：US46837074

申请日：1974-05-09

Applicant: STANFORD RESEARCH INST

Inventor： HENRY DAVID W ,  STURM PRISCILLA A

IPC: C07D207/16 ,  C07D471/08 ,  C07D487/08 ,  C07D295/16

CPC classification number: C07D471/08 ,  C07D207/16 ,  C07D487/08

Abstract: Twelve analogs of diethylcarbamazine as prepared by acylation of 3- and 8-methyl-3,8-diazabicyclo(3.2.1)octane, 2-methyl-2,5diazabicyclo(2.2.2)octane, and 2-methyl-2,5diazabicyclo(2.2.1)heptane with diethylcarbamyl chloride, ethyl chloroformate, ethyl isocyanate, and cyclohexanecarbonyl chloride. These compounds are formally derived from diethylcarbamazine in possessing two- or one-carbon bridges over the piperazine ring. The compounds have utility as antifilarial agents and as bronchodilators.

Abstract translation: 通过酰化3-和8-甲基-3,8-二氮杂双环[3.2.1]辛烷，2-甲基-2,5-二氮杂双环[2.2.2]辛烷和2-甲基-2 ，5-二氮杂双环[2.2.1]庚烷与二乙基氨基甲酰氯，氯甲酸乙酯，异氰酸乙酯和环己烷碳酰氯。 这些化合物正式衍生自在哌嗪环上具有两个或一个碳桥的二乙基氨基甲脒。 这些化合物具有作为抗感冒剂和支气管扩张剂的作用。