公开(公告)号：US20170296652A1

公开(公告)日：2017-10-19

申请号：US15509605

申请日：2015-09-17

Applicant: STC.UNM

Inventor： Bridget S. Wilson ,  Diane Lidke ,  Lydia Tapia ,  Mark Schulyer ,  Avanika Mahajan

IPC: A61K39/35 ,  C07K14/435 ,  C07K14/415

CPC classification number: A61K39/35 ,  A61K2039/577 ,  C07K14/415 ,  C07K14/43509 ,  C07K14/4702

Abstract: This disclosure describes recombinant hypoallergens and methods of treating allergy that involve administering a recombinant hypoallergen to a subject. Generally, the recombinant hypoallergen includes at least one amino acid modification compared to a corresponding wildtype allergen. As a result, the recombinant hypoallergen binds to IgE that specifically binds to the allergen, but induces release of histamine from basophils to a degree less than the wildtype allergen.